Agents targeting angiogenesis in older patients should be disease-specific.

2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Agents targeting angiogenesis in older patients should be disease-specific.

"Angiogenesis is impaired in aged tissues. It is probable that this deficit contributes to the increased severity of vascular diseases observed in older persons. The changes in angiogenesis that occur with aging have been noted at the molecular, cellular, and physiologic levels of regulation," researchers in the United States report.

"Components of the neovascular process that are influenced by age include endothelial cells, the hemostatic cascade, neuro-chemical mediators, and growth factors and their cognate receptors. The structural and …